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Effects of Ibuprofen on Magnitude & Duration of Aspirin

Posted on: 12/05/2011

F. Gengo, L. Rubin, M. Robson, M. Rainka, M. Gengo, D. Mager, V. Bates
Journal of Clinical Pharmacology; Volume 48, Number 1; Jan 2008 :

This study was designed to measure the magnitude and duration of inhibition of platelet aggregation following doses of aspirin or ibuprofen alone or taken in combination in a group of healthy volunteers. Ten normal volunteer subjects underwent 3 randomized treatment sessions: aspirin 325 mg alone, ibuprofen 400 mg alone, and ibuprofen 400 mg, followed by dosing with aspirin 325 mg 2 hours thereafter. In addition, a confirmatory study was performed in patients. Full Article