DENT Ketamine Clinic | Ketamine Infusion and Spravato™ (Esketamine) Treatment



Depression, Chronic Pain, and Migraine affects more than 16 million Americans every year. Our team of health professionals, nurses, management, and caring staff work together to create a warm and inviting environment for patients.

The DENT Ketamine Clinic provides high-quality care and counseling for people suffering from afflictions, where Ketamine infusions have proved to be a successful treatment choice. To make an appointment with our Ketamine Clinic, please call us at 716-961-9204.


About Ketamine

Ketamine is an anesthetic that was approved by the FDA in 1970. It quickly became one of the most widely used anesthetics in the world. Unlike opioids, it does now have any association with any physically addictive properties.

Ketamine’s safety and effectiveness profile is so good it is on the World Health Organization’s List of Essential Medicines. Only those medicines that are most effective and safe make it to this list.

Unlike many other anesthetics, Ketamine does not depress patients’ breathing or circulatory systems. Because of this, Ketamine is commonly used on the battlefield and in environments without adequate monitoring equipment. Ketamine can be used as a treatment for: Depression, Headache/Migraines, and Chronic Pain. With the appropriate order, our clinic will accept referrals from internal and external providers.

Ketamine has been shown to stimulate neuron growth in the brain in as quickly as one hour. Many scientists studying Ketamine are focusing on the neurotransmitter glutamate. This plays a crucial role in neural activation.

Ketamine Therapy has also been found to be a potent anti-inflammatory, which is also being studied for its positive effects. While the studies of “how” continue, the life-enhancing results are seen daily at the DENT Ketamine Clinic.


Our Mission


The DENT Ketamine Clinic is dedicated to improving the lives of those suffering from Migraine, Chronic Pain, and Depression. We hope to give our patients a higher quality of life and provide a safe, relaxing environment to maximize treatment success.

DENT provides the highest quality and compassionate patient care to the Western New York region. This is a direct result of a tireless commitment to staying at the forefront of medical advances and breakthrough technology.

We maintain valuable partnerships with other specialized clinicians. We offer a dedication to employing the brightest minds in the medical and clinical research fields. When you come to DENT, you are receiving the best care possible.


Ketamine and Mental Health

Depression is the leading cause of disability in people between the ages of 15 –44. Major depression is a common debilitating disorder affecting 10%–15% of the population per year.

Ketamine is an NMDA receptor antagonist and an AMPA receptor stimulator. AMPA stimulation results in BDNF (brain-derived neurotrophic factor). BDNF stimulates the formation of new receptors and synapses (which are vital connections between neurons).

Research suggests that a deficiency in these connections is associated with major depressive disorder and other mood disorders, along with difficulties with sleep, overstimulation, and focus.

Ketamine has produced rapid reductions in depression symptoms in treatment-refractory patients in numerous studies and has performed well when other interventions had minimal impact. After an infusion, patients may see improvements in their mood within hours.


Ketamine and Migraines

A new study shows that the drug ketamine may provide some relief to patients for whom other drugs have been ineffective for Migraine.

How? Ketamine has been a safe and effective FDA-approved anesthetic for nearly 50 years. At a molecular level, Ketamine blocks the NMDA receptor. The NMDA receptor is responsible for the body’s underlying neural network and its ability to process pain signals to the central nervous system.

Over-activation of this receptor can result in excitotoxicity, resulting in a myriad of pain disorders. Ketamine is thought to correct this over-activation by blocking the NMDA receptor.

Researchers at Thomas Jefferson University Hospital in Philadelphia studied 61 patients who received continuous 3-7 day treatment with Ketamine.

The study reported that about 3-4 migraine patients saw improvements in their pain intensity at the end of the treatment period.


Ketamine and Chronic Pain


Chronic Pain has plagued human beings for millions of years. Many continue to suffer under its wrath despite traditional treatment modalities such as opiates (oxycodone/hydrocodone), NSAIDs (ibuprofen/naproxen), or GABA agents (gabapentin, pregabalin).

Ketamine has been used for pain management and sedation in the Emergency Department setting for many years. Ketamine infusions and topical formulations have been used to treat many painful conditions with excellent success rates where standard pain medications have failed.

There are many types of chronic pain syndromes. They can range from dull, achy, constant pain to sharp, stabbing, nerve type pain that is intermittently severe. These often coexist and are quite challenging to manage with typical treatment regimens.

Treating Complex Regional Pain Syndrome (CRPS/RSD) and treating chronic pain with Ketamine corrects a process known as central sensitization. This is when the body increases the intensity and number of pain signals over time.

Ketamine interferes with this process and is thought to block and “reset” pain signaling, providing relief where other treatments have failed. By blocking the NMDA receptors of peripheral nerves, peripheral nerve pain transmission is intercepted before reaching the spinal cord and brain.

This allows for the “rebooting” of central pain centers and desensitization to peripheral brain signals.


How does it work?


During the Infusion Process


We begin with one or two infusions, depending on the patient, to see if Ketamine Infusions are useful. The results from the initial Ketamine Infusions will indicate how many more will take place.

During the Ketamine Infusion, you will be awake. The dosage is not high enough to cause you to fall asleep. Still, you may feel tired during and after the treatment.

The length of each treatment varies from patient to patient. Many patients feel better during the treatment itself. Others notice a marked improvement in mood or pain levels within a day of treatment.

During the infusion, you may experience side effects, like an altered mental status, although you will be alert and able to talk. Patients have also reported blurred vision, slurred speech, mental confusion, nausea, and vomiting. You will return to a healthy mental state rapidly when the infusion is over.

Do not drive or operate machinery, care for others, or sign essential papers on the day of treatment. The patient must arrange a way of transportation as they will be unable to drive.



We will be monitoring you throughout the process. Our team will ensure that you are safe until the process is complete.

After the procedure, you will stay in the recovery area until your medical team feels that you are ready to go home. While receiving the infusions, you will have periodic evaluations to provide ongoing support.


Does my insurance cover Ketamine?


At this time, insurance companies do not pay for Ketamine treatments. The self-pay rate for each Ketamine Infusion is $450.

Do I need a referral?


Ketamine is a treatment option for a variety of disorders. Please call us at 716-961-9204 to see if a referral is necessary.


Other treatment options – Spravato™ (Esketamine)


Spravato™ (Esketamine) has recently been approved in nasal form by the FDA for depression and is available to our patients. Esketamine must be administered and monitored in an approved clinic.

Treatment with Spravato™ may provide numerous patients with the relief from depression they are seeking. Initial studies have shown that Esketamine has a positive effect on 36-58% of treatment-resistant depression patients.

We are currently providing this in addition to Ketamine IV Infusions. Esketamine treatments require 2 hours of observation in the clinic following each administration.


How much does Spravato™ (Esketamine) treatment cost?


Spravato™ is approved by most insurance companies for Major Depressive Order. Out of pocket costs may vary, check Janssen CarePath for more details.


Is Spravato™ (Esketamine) FDA-approved for depression?


Yes, Esketamine is FDA-approved for treatment-resistant depression.


How is it given?


It is a nasal spray administered in the office. The recommended course is twice a week for four weeks, then weekly for four weeks, then individually determined after that.


Is Ketamine or Spravato™ (Esketamine) for me?


Patients will go through a screening using several tests and procedures to determine if they are eligible for treatment. Ketamine infusions may be an effective treatment for patients with depression who have not benefitted from antidepressant medications.

Contact our office to arrange an appointment for an evaluation. All patients new to our office must have an evaluation before determining the suitability of treatment. Call and make an appointment with our Ketamine Clinic at 716-961-9204.

Call Us (716) 250-2000