Dent Neurologic

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Julia Burket

CogMS

CogMS – A Real-world Study Into Cognitive Impairment in People With Multiple Sclerosis The present study will investigate the correlation between objective and subjective cognition in multiple sclerosis. The study will also investigate the impact of covariates such as fatigue and depression, the relationship with the Expanded Disability Status Scale (EDSS) and brain volumetrics as …

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Generation HD-2

Intuition: A Brain Health Study Intuition is a virtual research study sponsored by Biogen, in collaboration with Apple, for participants between the ages of 21 and 86.* By joining us, you can help researchers investigate the role an Apple Watch and iPhone could play in: Measuring changes in thinking and memory in adults Studying longer-term …

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Intuition

Intuition – A Brain Health Study Intuition is a virtual research study sponsored by Biogen, in collaboration with Apple, for participants between the ages of 21 and 86.* By joining us, you can help researchers investigate the role an Apple Watch and iPhone could play in: Measuring changes in thinking and memory in adults Studying …

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ENVISION

ENVISION Trial  The objective of this study is to verify the clinical benefit of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) score as compared with placebo in participants with early Alzheimer’s disease. What is Alzheimer’s Disease? Alzheimer’s is …

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CALLIPER

CALLIPER Phase 2 CALLIPER trial of lead asset IMU-838, the company’s selective oral DHODH inhibitor, in patients with progressive multiple sclerosis (PMS). The trial, which is intended to run concurrently with and as a complement to the company’s twin phase 3 ENSURE trials in relapsing-remitting multiple sclerosis (RRMS), is focused on progressive forms of multiple …

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PROSEEK

PROSEEK To Potentially Help Slow Progression for People with Early-stage Parkinson’s Disease The PROSEEK Study is a clinical research study evaluating a once-daily investigational drug for people with early-stage Parkinson’s disease (PD). The investigational drug is being studied to see if it can slow the progression of Parkinson’s disease. It is designed to block a …

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Signal – AD

Signal- AD Trial The purpose of the study is to investigate safety, tolerability, the effects on cognition and brain metabolism of pepinemab in people with early AD dementia (early AD). The primary hypothesis being tested is whether pepinemab will be safe and provide benefits in clinical assessments of cognition and in brain metabolism as measured …

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NRX- 101

Testing the hypothesis that treatment with NRX-101 is superior to standard of care (lurasidone) in improving symptoms of depression as measured by the total Montgomery Åsberg Depression Rating Scale (MADRS-10) score in patients with bipolar depression and subacute suicidal ideation and behavior (SSIB) which does not require hospitalization.

ADNI4 Trial

ADNI4 Trial The ADNI4 is multi-center, a non-randomized, natural history, non-treatment study. 1,150 participants will be enrolled across three cohorts: cognitively normal (CN), mild cognitive impairment (MCI) and dementia (DEM). Participants between the ages of 55-90 (inclusive) will be enrolled at 59 sites in the United States and Canada. Approximately, 750 participants will be newly …

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